Rearrangement of TBL1XR1 (3q26.32) have been identified in various cancers involving different genes, including RARA (17q21) [32], HMGA1 (6p21) [33], TP63 (3q28) [34], RET (10q11.2) [35], and PIK3CA (3q26.32) [36, 37]. Here, PIK3CA is linked to cancer.