In AD, there is evidence of upregulation of early mitophagy markers (PINK1, BNIP3L) and decreases in master regulators of lysosomal and mitochondrial biogenesis, such as TFEB in later stages, suggesting an impairment in the latter stages of mitophagy/autophagy-lysosomal clearance [160]. The gene discussed is TFEB; the disease is Alzheimer disease.