MAPT and Cognitive impairment: Traumatic brain injury (TBI), which is also a risk factor for AD, was investigated by Sweeney et al. who showed that overexpression of Bcl2 associated athanogene 3 (BAG3) in hippocampal neurons of human tau knock-in (hTKI) mice increased autophagy flux and reduced Tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits [71].