[47] showed CD30 upregulation in cHL and ALCL cell lines might be linked by a self‐perpetuating loop through the mitogen‐activated protein kinase/extracellular signal‐regulated kinase pathway to the expression of JunB, a member of the activator protein (AP‐1) transcription factor family, with diverse effects including a possible link to malignant transformation. This evidence concerns the gene TNFRSF8 and anaplastic large cell lymphoma.