Lastly,since MPO enzymatic activity in phagocytic white blood cells (e.g.,neutrophils and macrophages) is the major source of HOCl in normalhuman physiology−, ,  and many AML patients are neutropenic at diagnosis,−,  we do not anticipate substantial issues associated with on-targetdelivery of cytotoxins to normal cells or activated neutrophils. This evidence concerns the gene MPO and acute myeloid leukemia.