Similarly, kidneys from SBPkd1 and Pkd1wt mice with moderately progressive disease exhibited 5- to 10-fold increased pERK/ERK ratio and increased c-Myc expression versus age- and strain-matched Pkd1+/+ kidneys (Figure 5, D and E, and Supplemental Figure 6), consistent with our previous demonstration of c-MYC upregulation in human ADPKD (29). This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.