The marked reduction in renal cell proliferation by genetic inactivation of Kcnn4 in tested PKD mouse models is consistent with antiproliferative effects of KCa3.1 inhibitors in T cells and vascular smooth muscle cells (89–91) but at variance with KCNN4 knockdown in epithelial cells or primary cultures of human ADPKD kidney cells (32). Here, KCNN4 is linked to autosomal dominant polycystic kidney disease.