PKD1 and autosomal dominant polycystic kidney disease: We tested senicapoc efficacy in early-onset, rapidly progressive loss-of-function Pkd1cko and Pkd1V/V mice and in slowly or moderately progressive SBPkd1 and Pkd1wt transgenic PKD models with gradual disease progression more closely resembling human PKD1-mutant ADPKD.