As an indication of malnutrition and resultant wasting syndrome, elevated asparagine synthetase (Asns) and reduced insulin growth factor 1 (Igf1) expression in livers from LEC Srebf2–/– mice were found (Figure 5B), which resemble Plagl2-knockout mice in which lacteals in jejunum are also dilated (26). Here, PLAGL2 is linked to nutritional deficiency disease.