Interestingly, CRB3 promotes activation of RhoA by interacting with RhoGEF proteins (such as Cysts in Drosophila) to drive apical constriction (57); conversely, loss of CRB3 reduces active Rho, resulting in decreased cell migration and contractility in squamous cell carcinomas (58). The gene discussed is RHOA; the disease is squamous cell carcinoma.