SPOP and invasive breast carcinoma: SPOP expression was significantly upregulated in 15 of the 34 tumor types, including kidney renal clear cell carcinoma (KIRC), head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), and breast invasive carcinoma (BRCA), and significantly downregulated in 14 tumor types, such as lung squamous cell carcinoma (LUSC), lung adenocarcinoma (LUAD), and colon adenocarcinoma (COAD) (Figure 4A).