A case-control study of 458 patients with non-Hodgkin lymphoma found that genetic variants in RIPK3 may be important in non-Hodgkin lymphoma development (53); Liu et al. found that chronic lymphocytic leukemia was unable to induce necroptosis by TNF-α/zVAD because of defects in RIPK3 and deubiquitinase cylindromatosis (CYLD), key molecules of the necroptosis signaling cascade (54). Here, CYLD is linked to B-cell chronic lymphocytic leukemia.