Conversely, YUMMER1.7 tumor cells showed a marked reduction in Ccl, Cxcl, Thbs, Visfatin, and Laminin signaling after anti–PD-1/anti-MIF treatment, indicating a disruption of key pathways involved in melanoma invasion, metastasis, and immune evasion (47–49). The gene discussed is THBS1; the disease is neoplasm.