COMT and migraine disorder: 2024). COMT (Catechol‐O‐Methyltransferase), alongside MAO‐A (Monamine Oxidase A), the main enzymes involved in tyrosine metabolism, were also significantly increased in migraine model rats (Zhu et al. 2022). The role of the dopaminergic system in migraine, including vascular regulation and blood‐brain barrier permeability, corroborated these findings, despite the small cohort, and highlighted DRD2/NcoI as a potential pharmacogenetic predictor of response to rizatriptan (Zhang et al. 2022; Asuni et al. 2007).