COMT and major depressive disorder: 2017; Sutherland et al. 2017), it has been associated with depression and anxiety in chronic migraine (Fernández‐De‐Las‐Peñas et al. 2019). This variant is particularly relevant for frovatriptan response, with Met/Met carriers showing poorer outcomes (Cargnin et al. 2015). Other COMT variants, such as rs6269 and rs4818, also influence triptan efficacy (Terrazzino et al. 2010).