2022). In a multi‐ethnic GWAS, 22 risk loci were found, 10 novel and three explicitly associated with migraine in females (CPS1 rs1047891, PBRM1 rs11718509, SLC25A21 rs10150336) (Choquet et al. 2021). Alongside genetic variants, epigenetic influences are under investigation: current insights point to microRNA profiling, DNA methylation, and histone modifications as potential biomarkers for migraine (Gallardo et al. 2023). This evidence concerns the gene PBRM1 and migraine disorder.