In stable acute PE patients, elevated cTnI was not predictive of 30‐day all‐cause mortality but did independently predict risk for fatal pulmonary embolism. The high negative predictive value of cTnI suggests it is useful for identifying patients at lower risk for PE‐related death, but it is less helpful alone for ruling out all‐cause mortality. Here, TNNI3 is linked to pulmonary embolism.