TARDBP and amyotrophic lateral sclerosis: As reported in the accompanying manuscript by Zeng et al.60, the authors investigated APA dysregulation more generally upon TDP-43 loss and show that it is widespread (in accordance with our findings in Fig. 1b), can occur in ALS/FTD-related genes60 and can lead to change in function29, underscoring the potential relevance of APA in disease pathogenesis.