Moreover, using the TCGA survival analysis database [46, 47] we found that high copy number of PDIA4 is associated with poor prognosis in many cancer types, including, Uterine Corpus Endometrial Carcinoma (UCEC)Thyroid carcinoma (THCA), Low grade glioma (LGG), mesothelioma (MESO),Prostate adenocarcinoma (PRAD) (Fig. S7A–E). Here, PDIA4 is linked to thyroid gland carcinoma.