Moreover, using the TCGA survival analysis database [46, 47] we found that high copy number of PDIA4 is associated with poor prognosis in many cancer types, including, Uterine Corpus Endometrial Carcinoma (UCEC)Thyroid carcinoma (THCA), Low grade glioma (LGG), mesothelioma (MESO),Prostate adenocarcinoma (PRAD) (Fig. S7A–E). The gene discussed is PDIA4; the disease is cancer.