Interestingly, genes encoding ATRX (α-thalassemia/mental retardation syndrome X-linked) and DAXX (death domain-associated protein 6), members of chromatin remodelling complex that are active at telomeres, are strongly associated with ALT and may be involved in ALT suppression, while their loss and/or mutations in these genes is associated with ALT activation (Amorim et al, 2016; Ren et al, 2018; Yost et al, 2019). The gene discussed is ATRX; the disease is thalassemia.