TRPV2 and heart disorder: However, apart from its action on TRPV2, tranilast also exerts pleiotropic effects on other targets in immune cells, fibroblasts, the cardiovascular system, and tumor cells, as reviewed by Darakhshan and Pour,609 and it needs to be further confirmed to what extent the beneficial effects of tranilast and lumin in cardiac disease models depend on TRPV2 inhibition.