TRPC3 channels are highly expressed in the central nervous system (CNS),166 with particularly prominent expression in the pituitary gland and Purkinje cells of the cerebellum.167., 168., 169. TRPC3 is also expressed in the cardiovascular system, notably in the heart170 and lungs of patients with pulmonary arterial hypertension.171. This evidence concerns the gene TRPC3 and pulmonary arterial hypertension.