TRPC5 and kidney disorder: Receptor-operated TRPC5 activation leads to the loss of actin stress fibers, resulting in a motile and noncontractile phenotype,230 which characterizes podocyte damage and contributes to proteinuria and kidney disease.231., 232., 233. In contrast, TRPC6 activation promotes the formation of actin stress fibers, establishing a contractile and nonmotile phenotype.230