,235 Furthermore, TRPC5 contributes to chemotherapy-induced multidrug resistance in tumor cells by increasing the expression of ATP-binding cassette subfamily B member 1 transporters, also known as P-glycoprotein 1 or multidrug resistance protein 1.234., 235., 236. TRPC5 additionally functions as a pressure sensor in aortic baroreceptors, stabilizing blood pressure,237 and mediates endothelium-dependent contraction of carotid arteries.238. The gene discussed is ABCB1; the disease is neoplasm.