A prominent theme is the role of TRPA1 in pulmonary and intestinal vagal afferents to sense irritants, thereby contributing to protective reflexes like cough and emesis or vomiting, but also in exaggerated responses, such as bronchial or visceral hypersensitivity, allergic responses, and chronic obstructive pulmonary disease (COPD), or its contribution to the development of various skin diseases, IR damage, migraine, and other forms of headache, as recently reviewed.1011. The gene discussed is TRPA1; the disease is migraine disorder.