MCOLN3 and neurodegenerative disease: Importantly, TRPML3 activity increases with increasing pH, suggesting that even under conditions of increased lysosomal pH, as often observed in lysosomal storage and neurodegenerative diseases, TRPML3 would still be active to drive lysosomal exocytosis similar to TPC2, the activity of which does likewise not depend on the luminal pH.1106