In addition, the impact of RIP140 inhibition on converting glycolytic fibers to a more oxidative phenotype suggests that targeting this coregulator may be useful for chronic diseases disproportionately affecting fast-twitch muscle including Duchenne’s muscular dystrophy, age-related sarcopenia, and amyotrophic lateral sclerosis (84). The gene discussed is NRIP1; the disease is amyotrophic lateral sclerosis.