In addition, the impact of RIP140 inhibition on converting glycolytic fibers to a more oxidative phenotype suggests that targeting this coregulator may be useful for chronic diseases disproportionately affecting fast-twitch muscle including Duchenne’s muscular dystrophy, age-related sarcopenia, and amyotrophic lateral sclerosis (84). Here, NRIP1 is linked to Duchenne muscular dystrophy.