EPAS1 and neuroblastoma: However, in two NOR clusters (nC6 and nC7) there was no significant enrichment of EPAS1 and in one undifferentiated cluster (nC2) there was no significant enrichment of MYCN, so to further validate that EPAS1 expression is associated with a more differentiated cellular state, we utilized a recently published study wherein single cell sequencing data from 6 different studies composed of 126 872 cells from 68 samples from 61 different neuroblastoma patients had been combined (24).