However, the clear correlation between N-type cells and high levels of EPAS1 as well as the upregulation of genes highly expressed in N-type cells but not the PNMT gene upon iHIF2α induction in neuroblastoma cells suggest a role for HIF2α in the generation of noradrenergic chromaffin cells but not adrenergic chromaffin cells. This evidence concerns the gene PNMT and neuroblastoma.