We also compared the HIF2α protein levels between doxycycline induced iHIF2α LAN-1 cells and human endothelial cells (HUVEC) and in VHL deficient clear cell renal cell carcinoma (ccRCC) cells (786-O) (SI Appendix, Fig. S4K). The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.