This revealed that EPAS1, besides from a strong enrichment in endothelial cells, is significantly enriched in clusters nC8 and nC9 from noradrenergic low-risk tumors (NOR-clusters) characterized by high expression of noradrenergic markers such as DDC and SLC18A1 and significantly negatively correlated with undifferentiated high-risk neuroblastoma with high MYCN expression (Fig. 1 J–M and SI Appendix, Fig. S1 O–S) (16). Here, EPAS1 is linked to neuroblastoma.