EPAS1 and neuroblastoma: Overexpression of HIF2α in MYCN-amplified neuroblastoma cells rapidly induces expression of a cohort of genes also enriched in the chromaffin lineage during normal adrenal gland development, including key enzymes such as TH, DDC, and DBH, but not PNMT, indicating a bias toward noradrenergic chromaffin cells (N-cells) rather than adrenergic E-type cells.