Both sodium–glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) reduce the risk of cardiovascular events, mortality, hospitalisation for heart failure and adverse kidney outcomes in individuals with type 2 diabetes at very high cardiorenal risk (i.e. with a history of CVD, heart failure or kidney disease), independent of their glucose-lowering effects [6, 7]. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.