TGFB1 and neoplasm: Developmental pathways, including hedgehog, Notch, IL6/JAK/STAT3, and TGFβ signaling, along with hallmarks linked to tumor progression, stemness capacity, and metastasis (e.g., angiogenesis and EMT), displayed a significant positive association with WNTHigh populations (Fig. 2E; Supplementary Fig. S3I and S3J).