Relapsed or refractory primary GI DLBCL demonstrated better outcomes than conventional relapsed nodal DLBCL.<h4>Conclusion</h4>These findings confirm the efficacy of front-line R-CHOP in primary GI DLBCL and suggest that primary tumor resection may be a useful component of treatment for localized primary colorectal DLBCL. The gene discussed is DDIT3; the disease is colorectal diffuse large B-cell lymphoma.