IGF2BP1 and gastroesophageal reflux disease: ρ-HESS and colocalization analysis further revealed shared genetic loci for GERD and CAD, specifically rs4643373 in IGF2BP1 (located in chr17: 45876022-47517400 and posterior probability for H4 > 0.75).<h4>Conclusions</h4>GERD is identified as an independent risk factor for CAD.