PRDX6 and bacterial infectious disease: In addition to regulation of GSH production, we also found that BLP‐trained macrophages augmented their antioxidative capability by upregulating several key antioxidant molecules such as SOD2, CAT, GSTA3, and PRDX6[69] In particular, the transcription factor NRF2 pathway, which plays an important regulatory role in resisting the oxidative stress response,[40] was significantly more activated in BLP‐trained macrophages than in naïve macrophages, while knocking out NRF2, the ability of BLP‐trained macrophages to resist ferroptosis upon bacterial infection was markedly impaired.