Analysis of proinflammatory cytokines and chemokines at different time points showed significant upregulation of Tnf, Mmp14, Il1b, Il1a, Il17ra, Cxcl1, Cxcl2, Ccrl2, Ccl3, Ccl4, and Ccl9 after bacterial infection. The gene discussed is CXCL1; the disease is bacterial infectious disease.