Compared with Nrf2+/+ BMDMs, BLP‐trained Nrf2−/− BMDMs displayed downregulated expression of GPX4, HMOX1, GSS, and FTL as revealed by Western blot analysis (Figure 7H), enhanced both intracellular ROS (Figure 7I,K), and ferrous ion (Figure 7J,L) levels as indicated by fluorescent staining, suggesting a crucial role for NRF2 in the process of BLP training to tolerate oxidative stress and to resist bacterial infection‐initiated ferroptosis. This evidence concerns the gene HMOX1 and bacterial infectious disease.