Sting knockdown reduced CD8+ T cells, granzyme B+, IFN‐γ+, and NK cells, and increased MDSCs in tumor tissues, and reversed the immunophenotype caused by Rfwd3 knockdown (Figure 5N–R), suggesting the role of STING inhibition in RFWD3‐caused pro‐tumor TME. Here, CD8A is linked to neoplasm.