More than 90% of lung cancers are associated with exposure tosmohaze,[29] and our previous work showed that RFWD3 expression is significantly elevated in smokers compared with nonsmokers.[20] We analyzed TCGA datasets[30] (https://cghub.ucsc.edu/, with approval by the National Institutes of Health number #24437‐4) and confirmed that smoker patients expressed a higher level of RFWD3 than nonsmoker patients (Figure 8A). Here, RFWD3 is linked to lung carcinoma.