RFWD3 and lung large cell carcinoma: Results showed that in A549 (Figure 1G,H), large cell lung cancer (LCLC) H1299 (Figure 1I,J), and LUAD H460 (Figure 1K,L) cells, transfected with negative control shRNA (shNC), cytoplasmic dsDNA was maintained at a relatively low level; in RFWD3‐knockdown cells, cytoplasmic dsDNA was significantly increased, and returned to a low level when RFWD3 was compensated by transfection of shRFWD3‐resistant RFWD3 (Figure 1G–L).