IRF3 and neoplasm: We found that the expression levels of p‐STING, p‐TBK1, p‐IRF3, and p‐STAT1 were markedly increased in the Rfwd3 knockdown group compared to the shNC group (Figure S4B, Supporting Information), indicating that knocking down Rfwd3 in tumor cells results in activation of the STING pathway in adjacent immune cells.