CircPRELID2 enhances OGT‐mediated PCBP1 O‐GlcNAcylation at Threonine 99 site in the cytoplasm, which disrupts the binding of PCBP1 to the 3′‐UTR of ZEB2, resulting in the reversal of ZEB2 translation silencing, and ultimately promoting the EMT and metastasis of GC cells. This evidence concerns the gene PCBP1 and gastric cancer.