Numerous studies have indicated that PCBP1, as a tumor suppressor that inhibits tumorigenesis and metastasis, is involved in the transcription, alternative splicing, and translation of many tumor‐associated genes, ferroptosis and autophagy.[39, 40] Given that in the cytoplasm, circPRELID2 facilitated OGT‐mediated PCBP1 O‐GlcNAcylation, we wondered whether O‐GlcNAcylation of PCBP1 affects its cytoplasmic functions, particularly in translation regulation. This evidence concerns the gene OGT and neoplasm.