Hypoxia is a prevalent microenvironmental characteristics of solid tumors, which contributes to angiogenesis, cell survival, recurrence, as well as invasion and metastasis by regulating target genes and non‐coding RNAs.[6, 7, 55] So far, numerous lncRNAs and miRNAs modulated by HIF1A have been implicated in cellular adaptation to hypoxia.[56, 57] However, whether circRNAs participate in hypoxia‐mediated aggressive behaviors in malignancies, particularly in GC, remains poorly understood. The gene discussed is HIF1A; the disease is gastric cancer.