Through integrated molecular, cellular, and biochemical analyses, we identified the oncogenic role of circPRELID2, generated through the collaborative induction of DYRK1A‐SFPQ‐SAM68 ternary complex and IRAlus, in the metastasis of GC under hypoxia and further elucidated the mechanism by which circPRELID2/OGT/PCBP1/ZEB2 axis contributes to the translation of ZEB2 protein. This evidence concerns the gene ZEB2 and gastric cancer.