In summary, these results reveal that a novel oncogene‐circPRELID2, which is generated by the DYRK1A/SFPQ/SAM68 complex in an Alu elements dependent manner under hypoxia, plays a critical role in facilitating ZEB2 protein translation via circPRELID2/OGT/PCBP1/ZEB2 axis, eventually facilitating the EMT and metastasis of GC cells. This evidence concerns the gene KHDRBS1 and gastric cancer.