In this study, we found that circPRELID2 enhances the interaction between OGT and PCBP1, subsequently facilitating OGT‐mediated PCBP1 O‐GlcNAcylation at T99, which disrupts the binding of PCBP1 to the 3′‐UTR element of ZEB2, eventually reversing ZEB2 translational silencing and promoting GC EMT and metastasis. The gene discussed is PCBP1; the disease is gastric cancer.