These findings reveal a new regulatory mechanism of circRNA biogenesis, and also uncover that circPRELID2 participates in the translation of ZEB2 during GC metastasis via the modulation of PCBP1 O‐GlcNAcylation, which provides a promising prognostic biomarker and therapeutic target for GC metastasis. This evidence concerns the gene PCBP1 and gastric cancer.