We further performed multiplex immunofluorescence (mIF) of CD3, CD8 and GZMK in RCC tissues, which validated the preference of GZMK+CD8+ Tem cells in the ICB‐sensitive tumors (p < 0.001) (Figure 1J), supporting its essential role in protecting against immune escape of RCC. This evidence concerns the gene GZMK and renal cell adenocarcinoma.