We then performed tissue distribution analysis to dissect the compositional changes in the ICB‐treated tumors and other tissue types, and observed a significant tissue‐specific predominant cell infiltration, characterized by EC and tubular cell infiltration in normal kidney tissue, the infiltration of stromal (PCs and CAFs) and tumor components in ICB‐naïve samples, the infiltration of macrophages in ICB‐resistant samples, CD8+ T cell infiltration in ICB‐sensitive samples and B cell, monocyte and NK cell infiltration in PBMC (Figure 1C,D). This evidence concerns the gene CD8A and neoplasm.