Together, we have constructed a comprehensive ICB response‐governed TME atlas of RCC, which illustrates an aggressive and immunosuppressive ecosystem with extensive cellular and molecular alterations in ICB‐resistant patients, including aberrant infiltration of macrophages, diminution of cytotoxic CD8+ T cells, and hypoxic and metabolic reprogramming of tumor cells. This evidence concerns the gene CD8A and renal cell carcinoma.