Collectively, we concluded that MARCO could impair the tumor‐recognition and antigen‐presentation capacity of TAMs via the down‐regulating MHC‐I molecules, which is achieved by the SOCS1‐mediated blocking of JAK1 kinase function, thereby facilitating the inhibition of JAK1‐STAT1 pathway and downstream NLRC5‐MHC‐I pathway. Here, NLRC5 is linked to neoplasm.