A subclass of immunosuppressive TAMs has been shown to be represented by MARCO, which is linked to other pro‐tumoral markers such IL4R, CHIA, CD163, and EMT markers.[52] Quantitative reverse transcription polymerase chain reaction (RT‐qPCR) of these RCC‐derived TAMs showed the similar pattern, with MARCO expression linked to M2‐like phenotypic genes (Ccr2, Cx3cr1, Tgfb etc.)and M2‐connected genes (Il10, Csf1r, Arg1, etc.), but not M1 genes (Nos2, Il12b, H2‐ab1, etc.)(Figure 4D). The gene discussed is IL12B; the disease is renal cell adenocarcinoma.