LEP and anorexia nervosa: Here combining single-cell Ca2+ imaging and cell-type-specific neuronal activity manipulations in those freely behaving mice, we identified a leptin-sensitive population in the LH that enables adaptive behavioral responses under various anxiogenic conditions—exploration of exposed terrain to expand the radius of action space, eating despite an anxiogenic environment and limiting maladaptive excessive locomotion in an anorexia nervosa disease model.