To explore TME features of untreated TP53-mutant versus TP53 WT pMMR colon cancer, we analysed transcriptomic and genomic data from The Cancer Genome Atlas (TCGA) and atlas and compass of immune–colon cancer–microbiome interactions (AC-ICAM)29 cohorts (Extended Data Table 3). Here, TP53 is linked to malignant colon neoplasm.