CTCF is known to play a key role in organizing chromatin into highly self‐interacting topologically associated domains (TADs), also acting as a TF controlling the expression of many genes by binding to their TSSs.[48] CTCF was involved in a large scale of biological activities, including genome organization, carcinogenesis and inflammation responses.[49, 50, 51] Our study pointed a new mode of function of CTCF in promoting HSP90AB1 transcription in psoriasis. The gene discussed is CTCF; the disease is psoriasis.