This dysregulated translational control affects the production of androgen receptor (AR) and major histocompatibility complex class I (MHC‐I), thereby driving castration resistance and enabling immune evasion.[38] In this study, we discovered that MITF is essential for the progression of GC, possibly by promoting purine synthesis, thereby extending the tumorigenic roles of MITF. This evidence concerns the gene MITF and gastric cancer.