Recent genomic studies have further refined DLBCL taxonomy, identifying genetic subtypes such as MCD (MYD88/CD79B), BN2 (BCL6/NOTCH2), N1 (NOTCH1), and EZB (EZH2/BCL2), each with distinct pathogenic mechanisms and prognostic implications. This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.