Indeed, 6 out of 10 leading TFs have direct evidence and some experimental validation of their involvement in colon cancer risk and progression: ZNF334 [105], FOXD2 [106], FOXD3 [107], POU3F3 [108], NR1H4 [109], and VSX2 [110]. Here, POU3F3 is linked to malignant colon neoplasm.