ZNF146 and hyper-IgE syndrome: While we know that zinc finger proteins (ZNFs) are still not well characterized, hindering the functional annotation of module 4 where 9 out of 10 top TF are ZNFs, we found that ZNF341, which is the fourth highest-ranking hit for modularity contribution (Supplementary Fig. S12), is a regulator of STAT3 and plays a key role in hyper-IgE syndrome (HIES), a condition that often manifests as severe and chronic bacterial infections [111].