It is finally worth mentioning that the cancer driver TFs are only overrepresented in cluster E, with 19 TFs (CAMTA1, HLF, IRF4, STAT5A, HOXB13, ETV4, GATA2, STAT5B, HOXC13, FOXA1, ATF1, MGA, PRRX1, IKZF3, ERF, HOXA13, DOT1L, MNX1, TP53) annotated in the OncoKB dataset (Fisher’s exact test OR = 1.84, P = 0.005) and 15 annotated in the Cancer Gene Census dataset (Fisher’s exact test OR = 1.84, P = 0.013). Here, TP53 is linked to cancer.