For example, during Zika virus (ZIKV;Flaviviridae) infection, TRIM7 was found to catalyze theK63-linked ubiquitination of the viral envelope protein, which enhanced virioninfectivity and viral dissemination (67).Consequently, ZIKV replicated less efficiently in the brain and reproductivetissues of TRIM7-/- mice (67).Thus, as with other TRIM family members (68), TRIM7 can play very different roles during viral infection,depending on the context. The gene discussed is TRIM7; the disease is infection.