Interestingly, FACT has been reported to have additional roles outside of theFEAR pathway during infection that can either help or hinder viral replication.For example, RNAi screens identified both hSpt16 and SSRP1 subunits assuppressors of transcription by integrated retroviruses, such as humanimmunodeficiency virus-1 (HIV-1; Retroviridae) (90). Here, SUPT16H is linked to infection.