Furthermore, suppression of intestinal FXR signaling significantly reduced the beneficial effects of VSG microbiota transfer on serum TG levels and hepatic steatosis (Fig. 8G, I, and J) but did not affect the liver-to-body weight ratio or the serum levels of TC, ALT, or AST (Fig. 8F through H). Here, NR1H4 is linked to Hepatic steatosis.