Building on emerging evidence that certain secreted proteins exhibit distinct intra‐ and extracellular functions, we hypothesized that CXCL2, a chemokine classically associated with neutrophil recruitment, might similarly display dual functionality.[29] To evaluate this, we first investigated the extracellular role of CXCL2 by treating HCC cells with recombinant CXCL2 protein. This evidence concerns the gene CXCL2 and hepatocellular carcinoma.