CD8A and neoplasm: Cholesterol metabolism plays a pivotal role in tumor progression and the regulation of the immune microenvironment.[46] Multiple studies have reported that cholesterol and its metabolites can establish an immunosuppressive microenvironment and attenuate the antitumor effects of CD8+ T cells, macrophages, neutrophils, and so on.[47, 48] In this study, we found that the addition of exogenous cholesterol or overexpression of SREBF2 reversed the polarization of neutrophils toward the antitumor phenotype induced by CXCL2 overexpression.