CXCL2 and hepatocellular carcinoma: Among them, the frequent CNV depletion (40%) and significantly low expression of CXCL2 piqued our interest (Figure 1C,D) because many studies have suggested that CXCL2 could attract neutrophils and reshape an immunosuppressive microenvironment, thereby facilitating HCC immune escape.[18, 19] Only a minority of publications proposed that high CXCL2 expression could inhibit the malignant behavior of HCC.[20, 21] Concordantly, the CXCL2 gene also had omnibus deletion in HCC patients from the TCGA‐LIHC dataset (Figure S1A, Supporting Information).