CXCL2 and hepatocellular carcinoma: These findings are paradoxical to previous studies reporting that high CXCL2 levels in tumors are prone to shaping the immunosuppressive microenvironment by recruiting neutrophils.[18, 19] However, a minority of studies have demonstrated that CXCL2 overexpression could inhibit HCC proliferation without detailed exploration.[20, 21] This dichotomy in CXCL2 function highlights the need for a deeper understanding of its mechanisms in HCC progression and potentially, the impact on therapy.