C5orf24 and cognitive disorder: A serious complication in patients with metabolic disorders is cognitive impairment—the decline or loss of attention, memory, perception, and executive ability, leading to dysfunction and reduced quality of life.[6, 38] Lipid accumulation and chronic neuroinflammation causes play a critical role in the onset and progression of cognitive disorders.[16, 39] In this study, we investigated the role of feimin in microglia and provided evidence supporting its regulatory role in LD accumulation and neuroinflammatory responses under lipotoxic stress.