A serious complication in patients with metabolic disorders is cognitive impairment—the decline or loss of attention, memory, perception, and executive ability, leading to dysfunction and reduced quality of life.[6, 38] Lipid accumulation and chronic neuroinflammation causes play a critical role in the onset and progression of cognitive disorders.[16, 39] In this study, we investigated the role of feimin in microglia and provided evidence supporting its regulatory role in LD accumulation and neuroinflammatory responses under lipotoxic stress. This evidence concerns the gene C5orf24 and Cognitive impairment.