The Csn6flox/flox mice were further introduced into this background by crossing with KPP mice, yielding KPPC (LSL‐KrasG12D/+; LSL‐Trp53R172H/+; Ptf1a‐CreERT2; Csn6flox/flox) mice, thereby enabling pancreas‐specific conditional KO of Csn6 in a tumor‐prone genetic background (Figure 1G). The gene discussed is COPS6; the disease is neoplasm.