RNA polymerase I (Pol I) mediates the transcription of 5.8S, 18S, and 28S rRNA in the nucleolus, while Pol III mediates the transcription of 5S rRNA outside the nucleolus.[35] CSN6 KD leads to downregulation of 18S rRNA, 5.8S, and 28S rRNAs, suggesting that CSN6 is positively involved in ribosome biogenesis, which is consistent with its role in promoting cancer cell growth as cancer cells have a strengthened rRNA transcriptional activity. This evidence concerns the gene COPS6 and cancer.