The results of western blotting suggested that the expression of key regulators in the cGAS‐STING signaling pathway, including p‐STING, p‐TBK1, and pIRF3, was upregulated after melanoma treatment with 5F/STFM/R‐ES or 5F/STFM‐ES, indicating that the antitumor immune response of BMDCs targeting melanoma was activated (Figure 4E). The gene discussed is CGAS; the disease is melanoma.