To determine the relative contribution of calpain-2 in obesity-accelerated AAA development, calpain-2 floxed mice were bred to mice with a tamoxifen-inducible form of Cre under control of either the ubiquitous promoter, chicken β-actin, or adipocyte-specific promoter, Adipoq. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.