We included a wide range of variables (age, sex, BMI, smoking, alcohol use, psoriasis duration, PASI score, arthritis, hypertension, diabetes, dyslipidemia, hyperuricemia, CRP, ESR, IL-6, TNF-α, and treatment indicators) in a LASSO logistic regression to identify the most pertinent predictors of cardiovascular comorbidity (Figure 1). The gene discussed is TNF; the disease is psoriasis.