To assay whether ESRP2, which has been previously reported to be associated with orofacial clefts (Cox et al., 2018; Rohacek et al., 2017), is also associated with congenital hypopituitarism, we analyzed clinical and genomic data in the Arcus database from the Children's Hospital of Philadelphia. Here, ESRP2 is linked to orofacial cleft.