ESRP1 and non-acquired combined pituitary hormone deficiency: Our finding of anterior pituitary dysmorphogenesis in Esrp1/2 null mice and zebrafish, which also display cleft of the lip and palate, supports an etiological link between orofacial clefts and congenital hypopituitarism that has been previously proposed (Akin et al., 2014; Bowers et al., 1988; Laron et al., 1969; McCabe and Dattani, 2014; Prodam et al., 2021; Roitman and Laron, 1978; Rudman et al., 1978).