However, high systolic BPV was associated with increased risk of CIND in males lacking the ɛ4 allele, and both dementia and CIND were increased in females lacking the ɛ4 allele, suggesting high BPV in late-life is an accelerator of deteriorating long-term cognition, particularly in the absence of ApoE ɛ4. The gene discussed is APOE; the disease is dementia.