APOE and dementia: When the Cox proportional hazards analysis was repeated for the association between BPV and incident dementia and CIND, stratified by presence or absence of ApoE ɛ4 allele (Table 3), the risk of dementia in males was no longer increased with high BPV; however, a significantly increased risk for CIND remained for males in the highest tertile compared to the lowest tertile for those without the ɛ4 allele (HR = 1.25, 95% CI = 1.09, 1.43; p = 0.001).