The presence and location of tumor-infiltrating lymphocytes (TILs) have been linked to patient survival.3 Recently, the presence of tertiary lymphoid structures (TLS), which form near tumors post treatment as an organized lymph-node-like structure, were also correlated with improved survival post treatment.4 TLS were linked with CD8+ T cell infiltration into tumors40 and were suggested to facilitate antigen presentation as well as T cell expansion and activation.41 The presence of TLS and brisk TIL infiltration indicates that activated CD8+ T cells enter the tumor. This evidence concerns the gene CD8A and neoplasm.