S100A1 and neoplasm: We noted that, in samples of non-responders that presented CD8+ T cell infiltration, CD8+ T cells were embedded diffusely in the S100a+ tumor mass or entered the tumor as single cells or doublets, rather than clustering within CRATERs (Figures S7B–S7E), altogether suggesting that CRATERs may represent a visual sign of an effective immune response in tumors.