To assess whether tumor killing occurs within CRATERs, we performed a whole-mount terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, enabling a 3D view of the tumor surface, on CpG ODN-treated vs. PBS- or non-treated tumors and B2M-intact or B2M-depleted tumors. Here, B2M is linked to neoplasm.