BRAF and melanoma: Human melanoma driver mutations, such as BRAF(V600E), induce endogenous melanoma growth in zebrafish,5 with shared genomic and morphological characteristics of human melanoma,5–7 and can be generated in zebrafish with a highly conserved immune system.8 To date, obtaining a 3-dimensional (3D), dynamic view of tumor-immune interactions in vivo has been challenging, limiting our understanding of the nature of the anti-tumor immune response within an intact tissue microenvironment.