HMOX1 and periodontitis: Moreover, TXNRD1 has emerged as a promising prognostic marker for T2DM risk, particularly in familial forms of the disease [45], while GCLC (p < 0.01) and GCLM as well as HMOX1 (both p < 0.05) appear to play a role under specific clinical conditions of periodontitis accompanying T2DM [43].