CLEC4M and COVID-19: Indeed, L-SIGN is coexpressed with ACE2in the respiratory tract and, as opposedto DC-SIGN, does not have the potential of hyper-activating inflammatorypathways, which may reinforce some of the deadly characteristics ofSARS-CoV-2 infections. Additionally,because of its narrow tissue distribution, selective targeting ofL-SIGN is also attractive for tissue-selective delivery of drugs,particularly in the liver. This motivatedus to pursue the search of selective L-SIGN ligands that ultimatelyled to the discovery of Man84.