MLYCD and Insulin resistance: In support of this, in vitro overexpression of malonyl-CoA decarboxylase (MCD, an enzyme that depletes malonyl-CoA) in hepatocytes was shown to reduce malonyl-CoA levels and reverse insulin resistance (Zou et al. 2023; Hu et al. 2005; Sacksteder et al. 1999), suggesting that lowering the malonylation potential can alleviate metabolic defects.