SIRT5 and neoplasm: This aligns with the idea that malonylation accumulation (due to a lack of SIRT5 “eraser” activity) pushes metabolic enzymes into a less active state, thereby blunting the Warburg effect and slowing tumor progression(Du et al. 2011; Yu et al. 2013; Abril et al. 2021; Kumar And Lombard 2018; Zhu et al. 2021; Hu et al. 2021).