TDP-43 aggregates were shown to colocalize with Tau NFTs in the amygdala and hippocampus of AD patients (Davis et al, 2017; Smith et al, 2017; Tomé et al, 2021), and proximity ligation and co-immunoprecipitation experiments have suggested that TDP-43 interacts with Tau in AD brains (Tomé et al, 2021). Here, TARDBP is linked to Alzheimer disease.