Interestingly, immunohistochemical (IHC) staining revealed the presence of both phosphorylated Tau (detected with the AT8 antibody), and cytosolically mislocalized TDP-43 in the frontal cortex and hippocampus of AD+ patients, but not in control brains (Fig. EV5A,B, for IHC images in the other patient groups see Appendix Fig. S7). This evidence concerns the gene MAPT and Alzheimer disease.