Alternatively, their surface might nucleate amyloid fibers, as shown for other condensate systems (Emmanouilidis et al, 2024; Linsenmeier et al, 2023; Shen et al, 2023), providing a possible mechanistic explanation for how Tau/TDP-43 co-aggregates in brains of AD+ patients may form. Here, TARDBP is linked to Alzheimer disease.