Over 60% of AD patients additionally feature cytosolic deposits of the nuclear DNA/RNA-binding protein TDP-43 (TAR DNA binding protein of 43 kDa) (Amador-Ortiz et al, 2007; Josephs et al, 2014b, 2014a; Kadokura et al, 2009; Tomé et al, 2020, 2021; Tremblay et al, 2011), first discovered in the affected brain regions of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients (Neumann et al, 2006). This evidence concerns the gene TARDBP and Alzheimer disease.