TARDBP and amyotrophic lateral sclerosis: Over 60% of AD patients additionally feature cytosolic deposits of the nuclear DNA/RNA-binding protein TDP-43 (TAR DNA binding protein of 43 kDa) (Amador-Ortiz et al, 2007; Josephs et al, 2014b, 2014a; Kadokura et al, 2009; Tomé et al, 2020, 2021; Tremblay et al, 2011), first discovered in the affected brain regions of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients (Neumann et al, 2006).