TARDBP and Alzheimer disease: In AD, TDP-43 deposits are mainly found in the limbic regions and frontal cortex (Amador-Ortiz et al, 2007; Arai et al, 2009; Josephs et al, 2015; Latimer and Liachko, 2021; Meneses et al, 2021; Tomé et al, 2020).