In summary, our data provide molecular insights into the interaction of Tau and TDP-43, which is the basis of Tau/TDP-43 co-pathology common in animal models and AD patients (Chornenkyy et al, 2019; Latimer and Liachko, 2021; Montalbano et al, 2020; Spires-Jones et al, 2017; Tomé et al, 2023). Here, TARDBP is linked to Alzheimer disease.