PLCE1 is a phosphoinositide-specific phospholipase C that converts phosphatidylinositol-4,5-bisphosphate into inositol-1,4,5-trisphosphate and diacylglycerol, thereby triggering Ca2+ release and profibrotic responses in activated hepatic stellate cells (aHSCs), which downregulation diminishes inflammation associated with liver fibrosis [146]. Here, PLCE1 is linked to Hepatic fibrosis.