NFKB1 and heart disorder: It has been fully confirmed in similar polyphenol quercetin, which is able to mitigate mitochondrial autophagy in the heart with its antioxidant capacity, inhibit the activation of the NF-κB pathway to reduce inflammation, and increase the α and β diversity of the gut microbiota to mitigate the imbalance of the intestinal environment induced by cardiac diseases, and also stabilize the ecological balance of the intestinal tract to slow down the onset of cardiac diseases [222,223].