Moreover, they showed higher values of glycemic (FPG and HbA1c) and inflammatory (CRP, TNF-alpha, and ESR) markers, as well as a lower GFR, lower levels of HDL cholesterol, and a higher prevalence of hypertension, diabetes mellitus, ischemic heart disease, peripheral artery disease, and cancer (Table 3). This evidence concerns the gene TNF and hypertensive disorder.