WNK2 and neoplasm: Remarkably, DEGs from PRKACA L206R organoids were significantly enriched in several pathways associated with tumorigenesis and tumor invasion, such as phosphatidylinositol 3-kinase-AKT, Rap1, extracellular matrix receptor, cell adhesion, and mitogen-activated protein kinase cascade, which have not been reported in previous ACA studies (Sato et al., 2014; Yanan et al., 2014; Zennaro et al., 2017).