Growth of a vascular network within solid tumors is an integral component of neoplastic growth beyond a few millimeters in diameter without becoming necrotic.70, 71, 72 The involvement of PI3K-AKT-mTOR in promoting the production of angiogenic factors, including VEGF, has been well established in human neoplasms and murine models.20 Here, PIK3CA is linked to neoplasm.